In 1970, McVie took an
MRC research fellowship at Edinburg University, Department of Therapeutics, investigating
Hodgkin lymphoma. In 1975 McVie became the Foundation Senior Lecturer at the Cancer Research Campaign Oncology Unit (currently
Beatson West of Scotland Cancer Centre) at the
University of Glasgow. Under
Gordon Hamilton-Fairley and
Sir Kenneth Calman, he trained in the
United States, spending sabbaticals at the
NCI,
Bethesda,
Paris,
Sydney,
Australia and
Amsterdam. In 1979, McVie became the Clinical Research Director at the
Netherlands Cancer Institute, and Consultant in Medical Oncology at the
Antoni van Leewenhoek hospital in
Amsterdam. He developed a
drug development laboratory, and a clinical research unit, for Phase 1 and 2 drugs, plus establishing intraperitoneal therapy in
ovarian cancer and limb perfusion in localised
sarcoma and
melanoma. At the European Organisation for Research and Treatment of Cancer (
EORTC) he started the
lung cancer group and researched standard
chemotherapy / irradiation regimes which were adopted for small and non small cell lung cancer,
mesothelioma and
thymoma. As Chair of the Pharmacology and Metabolism Group he developed a platform for young investigators to present new molecules and their pharmacology. He was elected President of EORTC and initiated the present Drug Development Group in
Brussels, and with NCI support, the European New Drug Development Network and the joint EORTC, NCI, CRC Formulation Committee for anti cancer molecules. In 1989 McVie became the Scientific Director then Director General of the
Cancer Research Campaign. During this time over 60 new drugs were taken from laboratory to clinical trial, and
carboplatin,
temozolomide,
olaparib and
abiraterone, all important “breakthrough” anticancer drugs, emerged. In the UK he was one of the architects of the Cancer Trials Networks in Scotland, Wales, and England, and was a founding member of the
National Cancer Research Institute, UK. Having overseen a doubling of Cancer Research Campaign charitable income, he led the merger with ICRF to found Cancer Research UK (CRUK), the largest cancer charity in Europe. In 2002 McVie became joint CEO of Cancer Research UK with Sir
Paul Nurse, where he continued to support new molecule testing and support start-up companies. Then in 2003 McVie founded a new endeavour, Cancer Intelligence, then with the late Umberto Veronesi - a free online global cancer journal ecancer.org, which was published for eleven years in Zurich, then moved to become a UK charity. In 2004 McVie became a Senior Consultant of Clinical Research at the
European Institute of Oncology, Milan. He set up a clinical research unit to test new molecules and devices, and synergised the new institute with other leading cancer centres throughout the world. In 2016 he joined the Italian Institute for Molecular Oncology in Milan. == Honours and distinctions ==