In May 2023, she stood for the NDC primaries for
Essikado-Ketan. She won the primaries accumulating 1,043 votes to win the contest ahead of Sebastian Spio-Garbrah and Henry Abbey-Hart who polled 85 and 18 votes respectively. Ayensu-Danquah, in the
2024 General Elections, contested the Essikado-Ketan constituency against Charles Bissue, the candidate for the
New Patriotic Party (NPP). She secured 26,166 votes (59.58%), narrowly defeating Charles Bissue, who garnered 17,754 votes (40.42%). This victory marked the first time in over a decade that the National Democratic Congress (NDC) captured the parliamentary seat in the constituency. She was nominated and appointed Deputy Minister of Health in 2025, under the administration of
John Dramani Mahama. As a legislator and health professional, she has focused on strengthening healthcare systems, improving access to medical services, and advocating for gender equality in leadership. She is currently a Secretariat Member of the African High-Level Ministerial Committee (AHLMC) helping to reform of the Africa's global health architecture. == Personal life ==