After graduating from university, Boelke's application for a position at the
Sydney Hospital for Sick Children was declined because she was a woman, In May 1894 she married her fellow medical graduate, German-born Paul Wilhelm Rudolph Boelke. In 1909 she was hired by the New South Wales Department of Public Instruction as an assistant instructing medical officer, but she was forced to resign in 1915 after the anti-German
British Medical Association questioned her suitability for the role. She founded the Professional Women's Association in 1912 with the aim of uniting professional women to campaign for improvement of women's social standing. She was a convenor of the
National Council of Women of New South Wales' health committee during 1913–26, a vice president of Sydney's Town Planning Association, and a founding member of New South Wales branch of the
League of Nations Union in 1921. She was employed by
Berlei, an Australian lingerie manufacturer, from 1923 to 1926 as a medical director, a role that involved overseeing the welfare of the company's female workers and ensuring the "correct anatomical lines of their garments". ==Later life==