Wyshak's epidemiological research helped clarify observed relationships between
physical activity (exercise) and reduced
breast cancer and depression risks. While at Yale, Wyshak used twins as a model to examine survival statistics for twins and to examine inheritance of genes. She also investigated people's willingness to engage in risky behavior, a topic she examined based on a comparison between doctors and lawyers. Wyshak and
Rose Frisch's collaborative work determined that exercise reduced risk of certain cancers, and that drinking carbonated beverages increased the likelihood of bone fractures in young girls. Wyshak went on to investigate the link between soda consumption by adolescent girls and bone fractures, research that was broadly covered by the media. Her research also demonstrated that female athletes have a reduced risk of breast cancer in their later years, she uncovered historical shifts in the age of menstruation for girls, and examined
delayed menstruation in young ballerinas. ==Selected publications==