Granule cell dispersion

There are currently two hypotheses for the mechanism. It might be a consequence of a migration disorder, and the first hypothesis considers an initial injury that release toxin(s) that affect the normal migration of granule cells. The second hypothesis concerns the role of reelin (see below). Reelin role in temporal lobe epilepsy Reelin is required for normal neuronal lamination humans, and the lack of this expression can lead to migration defect associated with temporal lobe epilepsy ==References==