In humans, absence of the palmar grasp reflex or persistence of the reflex can both be indicators of
neurodevelopmental abnormalities. In a normal infant, the palmar grasp reflex is present during the first three months of age and disappears by six months of age. Disappearance of the reflex has been attributed to conscious and voluntary hand use. Based on collected evidence, there is no significant difference between the reflexes of normal-term and pre-term infants. Absence of the grasp reflex could indicate a neural communication error with the spinal cord. In other words, signals from the stimulation of tendons in the palm are being interrupted before they have a chance to make it to the spinal cord, resulting in a lack of the reflex. Absence of the grasp reflex could also be an indicator of
peripheral nerve injury or injury to the spinal cord. Persistence of the grasp reflex could be an indication of brain
lesions or
cerebral palsy. Presence of the reflex in infants older than four months could be an indicator of damage to the
central nervous system. This damage could be a result of neural degeneration, lack of oxygen in the brain, or other genetic factors. Any abnormal response for this reflex could produce suspicion for an underlying disease that would need to be addressed. That is why the elicitation of this grasp reflex is part of neurological examinations for newborns. ==References==