The product of this gene belongs to a small family of
adaptor proteins that are known to interact with a number of
receptor tyrosine kinases and
signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with
epidermal growth factor receptor (EGFR) and
ephrin receptors. The protein plays a role in the
integrin signaling pathway and
cell migration by binding with
focal adhesion kinase (FAK).
Alternative splicing results in multiple transcript variants encoding different
isoforms, although the full-length natures of only two of the variants have been determined to date. == Clinical significance ==