The diocese has existed since at least 1724, serving primarily the Greek and Arab Christian population. In 1818, there was a riot between the Orthodox and Catholic population in Aleppo, and in 1850 there was a pogrom against the Christian community instigated by the Muslim community. During the
Syrian Civil War, the metropolitan
Paul Yazigi, along with
Syriac Orthodox Archbishop of Aleppo
Yohanna Ibrahim by militants on April 22, 2013; as of 2023 they are still missing. Most of the Christian community has fled due to the ensuring civil war and resulting sectarianism. In December 2024, the
Greek government organized a relief effort to evacuate most of the remaining 50 Greek speaking Christian families left in Aleppo. ==List of bishops==