Professional baseball was first played in
Greeneville, Tennessee, by the
Greeneville Burley Cubs in the
Appalachian League in 1921. They remained in the league through 1925 and returned for a second stretch from 1938 to 1942. The circuit's vacancy was filled by the
Cincinnati Reds, who placed a
Rookie-level affiliate in Greeneville known as the Greeneville Reds. The 10–2 loss was attended by 2,388 fans. Led by
manager Gookie Dawkins, Greeneville concluded their first season with a 28–40 record, placing fifth in the West Division, 15 games back. The Reds finished last again in 2019 after compiling a 26–41 season, games out of first place. The start of the 2020 season was postponed due to the
COVID-19 pandemic before ultimately being cancelled on June 30. In conjunction with a contraction of Minor League Baseball beginning with the 2021 season, the Appalachian League was reorganized as a
collegiate summer baseball league, and the Reds were replaced by a new franchise in the revamped league designed for rising college freshmen and sophomores. ==Season-by-season results==