Yalobusha closed during the
American Civil War and its buildings were used for hospitals. At the end of the war, Mrs. Emma Holcombe purchased the school building and its property, reopening it in 1866. No later than August 1867, Holcombe renamed the school Emma Mercer Institute. Under Holcombe's leadership, the Emma Mercer Institute emphasized "sound learning, without pretense and show" and "discipline and order, enforced by firmess, and courtesy." By 1875, the school had financial problem. The local
Grange unsuccessfully attempted to buy the institute and turn it into an industrial school. A stock company purchased the property and turned the school into the Grenada Female College. ==Grenada College==