Papazacharias began his career in
Anagennisi Epanomi. He joined
Iraklis in 1999. He stayed in
Iraklis for 11 years, until 2010. He has over 118 performances with blue-white jersey and scored 6 league goals. In 2003-2004-2005 years, Iraklis was in very good form, finishing 4th behind
Olympiacos,
Panathinaikos and
AEK Athens, with Papazaharias being in first eleven in center-back duo, with
Tasos Katsabis. He was appointed as the captain for
Iraklis in 2007. In 2010 Papazacharias transferred to local rivals
Aris, but an injury left him out for about 4 months. During his first season at Aris, he played in only 3 matches. On 30 June 2019,
Thyella Kamari F.C. announced that they had signed Papazaharias. ==References==