N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (
GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (
GRIN2A), NMDAR2B (
GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (
GRIN2D). == Interactions ==