The Gruber Prize in Neuroscience, established in 2004, is one of three international awards of US$500,000 made by the Gruber Foundation, a non-profit organization based in Yale University in New Haven, Connecticut. It is awarded annually to scientists from around the world for significant discoveries that have enhanced the comprehension of the neurological system. The prize comprises the cash award, a gold medal engraved with the recipient's name, and a citation detailing the accomplishment for which they are being recognized.