Tagliaferri's involvement in politics began in
Grupo Sophia, a
think tank founded by
Horacio Rodríguez Larreta. In 2009, she was appointed General Director for Women in the Buenos Aires City Government; she would later be appointed as Undersecretary of Social Promotion and, in 2013, she was appointed to preside the city's Council of Children and Adolescents' Rights. As minister, Tagliaferri oversaw the demolition of the
Elefante Blanco, an abandoned hospital in the city's
Villa Lugano barrio, and its replacement with a new building for the Ministry of Human Development.
National Senator Ahead of the
2019 legislative election, Tagliaferri was internally selected to be the second candidate in the
Juntos por el Cambio list to the
Argentine Senate, after
Martín Lousteau. The list received 53.99% of the votes and Tagliaferri was comfortably elected alongside Lousteau. She was sworn in on 27 November 2019. Tagliaferri is one of the Senate's supporters of the
Voluntary Interruption of Pregnancy Bill brought forward by President
Alberto Fernández in 2020. ==Electoral history==