After his conquest of the
Roman city of
Antioch in 256, the
Sasanian King of Kings (
shahanshah)
Shapur I founded the city of Gundeshapur, situated between
Susa and
Shushtar. The city, constructed as a place to settle Roman prisoners of war, subsequently became a Sasanian royal winter residence and the capital of the
Khuzistan province. Gundeshapur was one of the four main cities of the province, along with
Susa,
Karka d-Ledan, and
Shushtar. Gundeshapur was mainly inhabited by Christians, and served as the
East-Syrian metropolitan see of
Bet Huzaye. Most scholars believe Shāpur I, son of
Ardashir I (Artaxexes), founded the city after defeating a Roman army led by
Emperor Valerian. Gundeshapur was a
garrison town and housed many Roman prisoners of war. Shāpur I made Gundeshapur his capital. In 489, the Eastern Christian theological and scientific center in
Edessa was ordered closed by the
Byzantine emperor Zeno, and relocated as the
School of Nisibis or Nisibīn, then under Persian rule with its secular faculties at Gundeshapur. Here, scholars, together with pagan philosophers banished from
Athens by
Justinian I in 529, carried out significant research in medicine, astronomy, and mathematics". Under the rule of Emperor
Khosrow I (531-579), called
Anushiravan "The Immortal" and known to the Greeks and Romans as 'Chosroes', Gundeshapur became known for medicine and erudition. Khusraw I gave refuge to various
Greek philosophers and Eastern Christian Assyrians fleeing religious persecution by the
Byzantine Empire. The emperor commissioned the refugees to translate Greek and Syriac texts into Middle Persian. They translated various works on medicine, astronomy, astrology, philosophy, and practical crafts. Anushiravan also turned eastwards and sent the famous physician
Borzuya to invite Indian and Chinese scholars to Gundeshapur. These visitors translated Indic texts on astronomy, astrology, mathematics, and medicine, as well as Chinese texts on herbal medicine and religion. Borzouye is said to have himself translated the still popular Indic
Pañcatantra from
Sanskrit into New Persian as
Kalīla wa-Dimna. Many Assyrians settled in Gundeshapur during the fifth century. The Assyrians were primarily physicians from
Urfa, which was, at that time, home to the leading medical center. Teaching in the Academy of Gundeshapur was done in Syriac until the city fell in the
early Muslim conquests, which destroyed the city and places of learning. == Gundeshapur under Arab-Islamic rule ==