The
Baltimore Orioles selected Henderson in the second round of the
2019 Major League Baseball draft with the 42nd overall pick. Henderson signed with the club for a $2.3 million signing bonus. After signing, he was assigned to the rookie-level
Gulf Coast League Orioles. Henderson finished his first professional season with a .259 batting average, one home run, and 11 RBI. After the 2020 minor league season was
canceled due to the COVID-19 pandemic, Henderson was added to the Orioles' alternate training site midway through the Major League season and then took part in the team's fall Instructional League. Henderson was named the best overall athlete in the Orioles' minor league system going into the 2021 season. He began the season with the
Low-A Delmarva Shorebirds and was promoted to the
High-A Aberdeen IronBirds and the
Double-A Bowie Baysox during the year. Over 105 games between the three teams, he slashed .258/.350/.476 with 17 home runs, 74 RBI, 28 doubles and 16 stolen bases. Henderson began the 2022 season at Bowie. He entered the season as a consensus top-100 prospect across baseball. Henderson batted .312/.452/.573 in 157 at bats with eight home runs and 35 RBI with 41 runs scored in 47 games for the Baysox before being promoted to the
Triple-A Norfolk Tides. On June 28, 2022, the day before his 21st birthday, he
hit for the cycle in a 8–2 win over the
Gwinnett Stripers. Henderson was selected to represent the Orioles at the 2022
All-Star Futures Game. The Orioles selected Henderson's contract on August 31, 2022, and promoted him to the active roster. He made the starting roster later that day, in a game against the
Cleveland Guardians. His first major league hit was a home run off of
Triston McKenzie Henderson batted .259 with four home runs and 18 RBIs in 34 games with the Orioles in 2022. Following the season, Henderson was named the 2022
Baseball America Minor League Player of the Year. The honor came after Henderson hit .297 with 19 home runs, 76 RBI, and 22 stolen bases in 112 games split between Bowie and Norfolk.
2023 On June 11, 2023, Henderson hit a 462-foot home run against the
Kansas City Royals, which was the farthest ever hit onto
Eutaw Street in the 31-year history of
Camden Yards. He had a pair of four-hit games in his
rookie season, beginning with a 14–1 away win over the
New York Yankees on July 6 when he also had two homers and five RBI within the first four innings. The other was a 12–1 victory over the
Athletics at the
Coliseum on August 20 when he was a
single away from becoming the first rookie in
Orioles history to
hit for the cycle, but got his second double of the game instead. He went 6-for-12 as the Orioles' best hitter during the ballclub's
American League Division Series (ALDS) loss to the
Texas Rangers. He finished the 2023 regular season with 28 HRs, 82 RBI, .814 OPS, and .255 AVG. On October 26, 2023,
The Sporting News announced Henderson as their
AL Rookie of the Year. Henderson was named the 2023
Major League Baseball Players Association Outstanding Rookie of the Year. He won the American League's
Silver Slugger Award for utility players. Henderson unanimously won the American League
Rookie of the Year Award.
2024 Henderson was awarded the March/April
American League Player of the Month Award in recognition of his strong start to the
2024 season. In 29 games, Henderson slashed .291/.356/.624 with 10 home runs, 24 RBI and six stolen bases. A day after his 23rd birthday, Henderson announced that he would be taking part in the 2024 Home Run Derby. Henderson was selected to his first All-Star game in 2024. He finished the 2024 regular season with 37 HRs, 92 RBI, .893 OPS, .281 AVG, and 21 stolen bases, all career highs.
2025 On January 28, 2025, Henderson, along with
Elly De La Cruz and
Paul Skenes was named on the cover for
MLB The Show 25, becoming the first Orioles player to make the cover since
Cal Ripken Jr. in 1999. On March 12, 2025, Henderson's contract was unilaterally renewed by the Orioles. == International Career ==