Gregson Wagner's first film role was as Lisa in the 1992 crime drama film
Fathers & Sons. She then had a small role in the movie
Buffy the Vampire Slayer. Following that film she starred in several TV movies including
Modern Vampires,
Hefner: Unauthorized, and
The Shaggy Dog. In 1995, she starred with her stepfather Robert Wagner in a
Hart to Hart TV movie. She starred in the
Wes Craven horror film
Mind Ripper. In 1996, she co-starred with
Jon Lovitz and
Tia Carrere in the comedy
High School High. She played Lou in the 1997 film
Two Girls and a Guy. Gregson Wagner played a small role in the 1998 thriller
Urban Legend. That same year she guest starred in an episode of
Ally McBeal and co-starred with
Vincent Kartheiser,
James Woods and
Melanie Griffith in
Larry Clark's crime drama
Another Day in Paradise. To avoid an
NC-17 rating, a rough sex scene with Kartheiser had to be removed from the theatrical version. In 2000, Gregson Wagner had roles in
Stranger Than Fiction, and
High Fidelity opposite
John Cusack. In 2001, she was regular cast member in the short-lived prime time soap opera,
Pasadena. In 2003, she played Barbara Richardson in the movie
Wonderland. In 2004, she had a role in the Hallmark movie,
Angel in the Family playing the part of Beth. In 2005 Gregson Wagner guest-starred on
Cold Case and
Medium. In 2006, she starred in two episodes of
ER: "Bloodline" and "21 Guns". From 2005 to 2007, she had a recurring role on the TV show
The 4400 as April Skouris, the sister of NTAC agent Diana Skouris. In 2008, she guest starred on
CSI: Crime Scene Investigation and
House M.D. In 2020, Gregson Wagner produced the documentary film
Natalie Wood: What Remains Behind, directed by
Laurent Bouzereau. ==Personal life==