Cardwell was born in Vermont but moved to
Steuben County, New York, in his early years. In January, 1841 he left home on a whaling voyage. After visiting many ports of the Pacific, he arrived in California in 1844, and for some time was a resident of Los Angeles. Cardwell married Maria Susana Wolfskill, daughter of Los Angeles rancher and agronomist
William Wolfskill in 1853. He constructed a new house on land adjoining the Wolfskill property in 1858. and Susana had four children: a daughter, Ellen, who died July 21, 1854, at the age of 1; William, born January 28, 1855, Charles, born February 17, 1857; and Leonora, born in September 1859—two months after Cardwell's death. Charles died in February 1859. Cardwell was approximately 40 years of age when he died on July 4, 1859. According to his obituary, "In 1850, he was thrown from a horse, and received injuries from which he never recovered." The U.S. Census Mortality Schedule ending June 1860 listed his cause of death as consumption, indicating that he had suffered from the disease for a period of one year. "His sufferings for a number of years have been great, but he has always displayed a most unconquerable spirit of energy and perseverence ." ==Military service==