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N-DEAOP-NMT

N-(3-Diethylamino-3-oxopropyl)-N-methyltryptamine (N-DEAOP-NMT), also known as desvinyl-LSD or 9,10-dinor-LSD, is a tryptamine derivative and a "partial" or simplified lysergamide which is closely related to the highly potent serotonergic psychedelic lysergic acid diethylamide (LSD). It is the analogue of LSD in which two of LSD's carbon atoms in the ergoline ring, those at positions 9 and 10, have been removed. This in turn renders the N-DEAOP-NMT molecule flexible and makes it a non-rigid tryptamine rather than an ergoline. The compound is pharmacologically active, as are a number of its analogues and derivatives, with activities of the compounds including serotonin 5-HT2A receptor agonism and LSD- or hallucinogen-like effects.

Pharmacology
N-DEAOP-NMT has been found to produce quantifiable oxytocic effects in animals. Relatedly, activation of serotonin 5-HT2A receptors in the brain is also the mechanism of action underlying the hallucinogenic effects of LSD and other serotonergic psychedelics. ==Chemistry==
Chemistry
Analogues and derivatives N-DEAOP-NET . The compound showed very weak oxytocic activity, 10-fold less potent than N-DEAOP-NMT, in a preclinical study. NDTDI is a tricyclic analogue of LSD and N-DEAOP-NMT in which only the carbon atom at position 9 of the ergoline ring system has been removed, as opposed to removal of both carbons at positions 9 and 10 as in the case of N-DEAOP-NMT. It has been encountered as an LSD-related designer drug and made illegal in parts of Europe. ==History==
History
N-DEAOP-NMT was first described in the scientific literature by 1952. N-DEAOP-NMT and other simplified non-rigid LSD analogues were notably reviewed and discussed by psychedelic chemist David E. Nichols in his Ph.D. thesis on LSD analogues and other psychedelics in 1973. N-DEAOP-NMT's derivatives N-DEAOP-NET and 5-MeO-N-DEAOP-NET, as well as LSD-like effects of these compounds, were first described in the literature by 1971, while 5-MeO-N-DEAOP-NMT and its serotonin receptor interactions were first described by 2005. ==See also==
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