Main •
Jean Smart as Deborah Vance, a revered stand-up comedian in the twilight of her career •
Hannah Einbinder as Ava Daniels, a young comedy writer and Deborah's writing partner •
Carl Clemons-Hopkins as Marcus, the newly promoted CEO of Deborah's company
Recurring •
Paul W. Downs as Jimmy LuSaque Jr., Deborah and Ava's manager at Latitude Arts Agency •
Megan Stalter as Kayla Schaeffer, Jimmy's assistant •
Martha Kelly as Barbara, a human resources representative at Latitude •
Mark Indelicato as Damien, Deborah's personal assistant •
Rose Abdoo as Josefina, Deborah's estate manager •
Joe Mande as Ray, a hotel clerk for the Palmetto •
Christopher McDonald as Marty Ghilain, CEO of the Palmetto Casino •
Jane Adams as Nina Daniels, Ava's mother •
Poppy Liu as Kiki, Deborah's blackjack dealer •
Kaitlin Olson as Deborah "DJ" Vance Jr., Deborah's daughter •
W. Earl Brown as Michael Schaeffer, Jimmy's boss and Kayla's father. Brown replaces
Brent Sexton, who played Michael in the first season. •
Michael Garza as Silas, Jimmy's temporary assistant •
Ming-Na Wen as Janet Stone, a talent manager with a grudge against Jimmy •
Angela E. Gibbs as Robin, Marcus's mother •
Luenell as Miss Loretta, Robin's friend •
Laurie Metcalf as Weed, Deborah's tour manager •
Susie Essman as Elaine Carter, Deborah's old friend and a director •
Ally Maki as Taylor, a television producer and friend of Ava's •
Caitlin Reilly as Jessica, a network executive
Guest •
Kirby Howell-Baptiste as Daisy, a British TV producer who previously interviewed Ava •
Wayne Newton as himself, a Las Vegas entertainer and Deborah's friend •
Carole Raphaelle Davis as Victoria Calle, Marty's girlfriend •
Lauren Weedman as Jo Pezzimenti, the mayor of Las Vegas •
Paul Felder as Aidan, DJ's husband and Deborah's son-in-law •
Rebecca Field as Lorna, a woman Deborah meets at a rest stop •
Polly Draper as Diana, Deborah's psychic •
Kimia Behpoornia as Lori, a comedian who opens for Deborah on one of her tour stops • Maleah Goldberg and
May Hong as Valentina and Morgan, a lesbian couple Ava meets on a cruise •
Harriet Sansom Harris as Susan Essig, a former stand-up comedian Deborah knew at the beginning of her career •
Devon Sawa as Jason, a younger man Deborah meets at a bar •
Kyle Gass as Axel, one of Deborah's stalkers •
Jessica Chaffin as Jill, Ava's pro bono legal advisor •
Paula Andrea Placido as Rian, Ava's tenant •
Lorenza Izzo as Ruby, Ava's ex-girlfriend ==Episodes==