A HAD
domain is found in several distinct proteins including: •
Phospholipid-translocating ATPase , a putative lipid-flipping enzyme involved in cold tolerance in
Arabidopsis •
3-deoxy-D-manno-octulosonate (KDO) 8-phosphate phosphatase (), which
catalyses the final step in the biosynthesis of KDO - a component of
lipopolysaccharide in
Gram-negative bacteria •
Mannosyl-3-phosphoglycerate phosphatase (), which
hydrolyses mannosyl-3-phosphoglycerate to form the
osmolyte mannosylglycerate •
Phosphoglycolate phosphatase (), which catalyses the
dephosphorylation of 2-phosphoglycolate • 5´-Nucleotidase (EC 3.1.3.5) which either catalyzes the hydrolysis of IMP. or IMP and GMP • Hypothetical proteins Human genes encoding proteins that contain this domain include: •
ATP8B3,
ATP8B4,
ATP10A,
ATP10B,
ATP10D == References ==