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Haplogroup L3

Haplogroup L3 is a human mitochondrial DNA (mtDNA) haplogroup. The clade has played a pivotal role in the early dispersal of anatomically modern humans.

Origin
Haplogroup L3 arose close to 70,000 years ago, near the time of the recent out-of-Africa event. This dispersal originated in East Africa and expanded to West Asia, and further to South and Southeast Asia in the course of a few millennia, and some research suggests that L3 participated in this migration out of Africa. A 2007 estimate for the age of L3 suggested a range of 104–84,000 years ago. More recent analyses, including Soares et al. (2012) arrive at a more recent date, of roughly 70–60,000 years ago. Soares et al. also suggest that L3 most likely expanded from East Africa into Eurasia sometime around 65–55,000 years ago as part of the recent out-of-Africa event, as well as from East Africa into Central Africa from 60 to 35,000 years ago. Haplogroups L6 and L4 form sister clades of L3 which arose in East Africa at roughly the same time but which did not participate in the out-of-Africa migration. The ancestral clade L3'4'6 has been estimated at 110 kya, and the L3'4 clade at 95 kya. According to other research, though earlier migrations out of Africa of anatomically modern humans occurred, current Eurasian populations descend instead from a later migration from Africa dated between about 65,000 and 50,000 years ago (associated with the migration out of L3). == Distribution ==
Distribution
L3 is common in Mozambique, Cameroon, Bioko Island, Northeast Africa, and some other parts of East Africa, L3 is rare in West Africa, but its sublineages are also frequent in the Arabian Peninsula. According to Maca-Meyer et al. (2001), "L3 is more related to Eurasian haplogroups than to the most divergent African clusters L1 and L2". L3 is the haplogroup from which all modern humans outside Africa derive. However, there is a greater diversity of major L3 branches within Africa than outside of it, the two major non-African branches being the L3 offshoots M and N. Subclade distribution L3 has seven equidistant descendants: L3a, L3b'f, L3c'd, L3e'i'k'x, L3h, M, N. Five are African, while two are associated with the Out of Africa event. • NEurasia possibly due to migration from Africa, and North Africa possibly due to back-migration from Eurasia. • L3a1 – Found across Eastern Africa. Estimated age of 35.8–39.3 ka. • '''L3b'f''' • L3b – Spread from East Africa in the Upper Paleolithic to West-Central Africa. Some subclades spread from Central Africa to East Africa with the Bantu migration. Beja • '''L3c'd''' • L3c – Extremely rare lineage with only two samples found so far in Eastern Africa and the Near East. Mozambique, Yemeni, • L3d3a1 – Primarily found in Southern Africa. • '''L3e'i'k'x''' • L3e – Suggested to have originated in the Sudan region, Central Africa or Mozambique about 45,000 years ago during the Upper Paleolithic period. It is the most common L3 sub-clade in Bantu-speaking populations. L3e is also the most common L3 subclade amongst Black Americans and Afro-Brazilians. • L3e1 – Particular common in Mozambique, the Tikar of Cameroon, as well as Burkina Faso, Nigeria, South Tunisia, South Morocco and EgyptL3i Almost exclusively found in East Africa. • L3h – Almost exclusively found in East Africa. L3x2a was observed in a 4,500 year old hunter-gather excavated in Mota, Ethiopia, with the ancient fossil found to be most closely related to modern Southwest Ethiopian populations. Haplogroup L3 has also been found among ancient Egyptian mummies (1/90; 1%) excavated at the Abusir el-Meleq archaeological site in Middle Egypt, with the rest deriving from Eurasian subclades, which date from the Pre-Ptolemaic/late New Kingdom and Ptolemaic periods. The Ancient Egyptian mummies bore Near eastern genomic component most closely related to modern near easterners. Additionally, haplogroup L3 has been observed in ancient Guanche fossils excavated in Gran Canaria and Tenerife on the Canary Islands, which have been radiocarbon-dated to between the 7th and 11th centuries CE. All of the clade-bearing individuals were inhumed at the Gran Canaria site, with most of these specimens found to belong to the L3b1a subclade (3/4; 75%) with the rest from both islands (8/11; 72%) deriving from Eurasian subclades. The Guanche skeletons also bore an autochthonous Maghrebi genomic component that peaks among modern Berbers, which suggests that they originated from ancestral Berber populations inhabiting northwestern Africa. A variety of L3 have been uncovered in ancient remains associated with the Pastoral Neolithic and Pastoral Iron Age of East Africa. == Tree ==
Tree
This phylogenetic tree of haplogroup L3 subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation and subsequent published research. Most Recent Common Ancestor (MRCA) • L1-6 • L2-6 • L2'3'4'6 • L3'4'6 • L3'4 • L3 • L3a • L3a1 • L3a1a • L3a1b • L3a2 • L3a2a • L3b'f • L3b • L3b1 • L3b1a • L3b1a1 • L3b1a2 • L3b1a3 • L3b1a4 • L3b1a5 • L3b1a5a • L3b1a6 • L3b1a7 • L3b1a7 • L3b1a8 • L3b1a9 • L3b1a9a • L3b1a10 • L3b1a11 • L3b1b • L3b1b1 • L3b2 • L3b2a • L3b2a • L3b3 • L3f • L3f1 • L3f1a • L3f1a1 • L3f1b • L3f1b1 • L3f1b2 • L3f1b2a • L3f1b3 • L3f1b4 • L3f1b4a • L3f1b4a1 • L3f1b4b • L3f1b4c • L3f1b5 • L3f2 • L3f2a • L3f2b • L3f3 • L3f3a • L3f3b • L3c'd • L3c • L3d • L3d1-5 • L3d1 • L3d1a • L3d1a1 • L3d1a1a • L3d1b • L3d1b1 • L3d1c • L3d1d • 199 • L3d2 • L3d5 • L3d3 • L3d3a • L3d4 • L3d5 • L3e'i'k'x • L3e • L3e1 • L3e1a • L3e1a1 • L3e1a1a • 152 • L3e1a2 • L3e1a3 • L3e1b • L3e1c • L3e1d • L3e1e • L3e2 • L3e2a • L3e2a1 • L3e2a1a • L3e2a1b • L3e2a1b1 • L3e2b • L3e2b1 • L3e2b1a • L3e2b2 • L3e2b3 • L3e3'4'5 • L3e3'4 • L3e3 • L3e3a • L3e3b • L3e3b1 • L3e4 • L3e5 • L3i • L3i1 • L3i1a • L3i1b • L3i2 • L3k • L3k1 • L3x • L3x1 • L3x1a • L3x1a1 • L3x1a2 • L3x1b • L3x2 • L3x2a • L3x2a1 • L3x2a1a • L3x2b • L3h • L3h1 • L3h1a • L3h1a1 • L3h1a2 • L3h1a2a • L3h1a2b • L3h1b • L3h1b1 • L3h1b1a • L3h1b1a1 • L3h1b2 • L3h2 • MN == Popular culture==
Popular culture
• Writer Bonnie Greer is a member of haplogroup L3. • Author Malcolm Gladwell is a member of haplogroup L3f1. • Musician Branford Marsalis is a member of haplogroup L3f1b. == See also ==
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