Pre-draft Landry participated in the
NFL Combine on March 4, 2018. Prior to the NFL draft, Landry was a popular mock draft pick for the
Green Bay Packers,
Detroit Lions and
Tennessee Titans.
Tennessee Titans 2018 season Landry was selected by the Tennessee Titans in the second round (41st overall) of the
2018 NFL draft. Landry signed his rookie contract on June 14, 2018. He made his NFL debut in Week 2 of the 2018 season against the
Houston Texans. During Week 4 against the
Philadelphia Eagles, Landry recorded his first NFL sack on
Carson Wentz. He finished the 26–23 overtime victory with four tackles, a sack, and a forced fumble. During Week 9 against the
Dallas Cowboys, Landry sacked
Dak Prescott once in the 28–14 road victory. Landry recorded a sack in each of the final two games of the season. Landry finished his rookie season with 4.5 sacks, 44 tackles, two pass deflections, and a forced fumble.
2019 season During Week 4 against the
Atlanta Falcons, Landry sacked
Matt Ryan twice in the 24–10 road victory. During Week 8 against the
Tampa Bay Buccaneers, he recorded a strip sack on
Jameis Winston and recovered the ball in a 27–23 victory. In the next game against the
Carolina Panthers, Landry recorded his first NFL interception off quarterback
Kyle Allen in the 30–20 road loss. Landry finished his second professional season with a then-career-high nine sacks along with 68 tackles, a forced fumble, two fumble recoveries, an interception, and a pass deflection. In the Divisional Round against the
Baltimore Ravens, Landry sacked quarterback
Lamar Jackson once in the 28–12 road victory.
2020 season During Week 2 against the
Jacksonville Jaguars, Landry intercepted his first pass of the season off a pass thrown by
Gardner Minshew late in the fourth quarter to secure a 33–30 victory for the Titans. Three weeks later against the
Buffalo Bills, Landry recorded his first sack of the season by spinning down
Josh Allen in the 42–16 victory. During a Week 9 victory of 24–17 over the
Chicago Bears, Landry recorded four tackles and a sack. Two weeks later against the
Baltimore Ravens, he recorded seven tackles and a sack in the 30–24 overtime road victory. In the next game against the
Indianapolis Colts, Landry recorded another sack in the 45–26 road victory. In the regular-season finale against the Texans, he recorded four tackles and a sack in the 41–38 road victory. Landry finished the 2020 season with 5.5 sacks, a then-career-high 69 tackles, an interception, and a career-high five pass deflections. In the Wild Card round of the playoffs against the Ravens, Landry led the team with 10 tackles (8 solo) and sacked quarterback Lamar Jackson twice during the 20–13 loss.
2021 season During the season-opener against the
Arizona Cardinals, Landry recorded three tackles and sacked Kyler Murray once in the 38–13 loss. Three weeks later, Landry recorded seven tackles and a sack in a 27–24 overtime road loss to the
New York Jets. In the next game against the Jaguars, he recorded seven tackles and sacked rookie quarterback
Trevor Lawrence twice in the 37–19 road victory. The following week against the Bills, Landry recorded eight tackles and sacked
Josh Allen twice in the narrow 34–31 victory. During a Week 8 overtime road victory of 34–31 over the Colts, Landry recorded five tackles, a sack, and a forced fumble. Two weeks later, he recorded five tackles and a sack in a 23–21 victory over the
New Orleans Saints. During a Week 14 shutout victory of 20–0 over the Jaguars, Landry recorded three tackles and a sack. Three weeks later against the
Miami Dolphins, he recorded three tackles and a sack in the 34–3 victory. Landry finished the 2021 season with a career-high 12 sacks, a career-high 74 tackles, and a forced fumble. The Titans finished atop the AFC with a 12–5 record and earned a first-round bye in the playoffs. In the Divisional Round round of the playoffs against the
Cincinnati Bengals, Landry had six tackles and 1.5 sacks in the 19–16 loss. On January 26, 2022, Landry was selected to appear in the
2022 Pro Bowl as an injury replacement. It marked his first career Pro Bowl.
2022 season On March 8, 2022, Landry signed a five-year, $87.5 million extension with $52.5 million guaranteed. On August 31, Landry tore his ACL in practice, prematurely ending his season. He was placed on injured reserve two days later.
2023 season Landry returned as a starter in 2023 alongside
Denico Autry and
Arden Key. In Week 14, Landry recorded three sacks and five tackles in a 28–27 win over the Dolphins, earning AFC Defensive Player of the Week. He finished the season with 69 tackles and 10.5 sacks.
2024 season Landry continued as a starting linebacker for the
2024 season. On a Week 12 road game against the
Houston Texans, Landry made a sack against
C. J. Stroud for his first career
safety during the final two minutes of the game, sealing off the Titans' victory in a 32–27 upset. He started all 17 games, finishing with 71 tackles, nine sacks, 18 pressures, and four pass deflections. On February 26, 2025, the Titans granted Landry permission to seek a trade, later releasing him on March 7 after failing to find a trade partner.
New England Patriots 2025 season On March 12, 2025, Landry signed a three-year, $43.5 million contract with the
New England Patriots. In his Patriots debut against the
Las Vegas Raiders, Landry tallied 2.5 sacks of Raiders quarterback
Geno Smith, though the Patriots would lose 20–13. In the 2025 season, he had 49 total tackles (27 solo), 8.5 sacks, and one forced fumble in 15 games. ==Career statistics==