Harvey N. Middleton was an American physician and cardiologist in Indianapolis, Indiana, who is best known for his efforts to open opportunities for black physicians to serve on the staffs of Indianapolis hospitals and for his community service. Middleton was born in Denmark, South Carolina, and received a Bachelor of Arts degree from Benedict College (1919) in Columbia, South Carolina. He attended two years of medical school at Boston University before transferring to Meharry Medical College, in Nashville, Tennessee, where he received a medical degree (M.D.) in 1926. Middleton took short courses for additional training at Harvard University; the University of London, England; the University of Michigan; Indiana University; and Michael Reese Hospital in Chicago. In 1928 Middleton moved to Anderson, Indiana, where he joined the staff of Saint Johns Hospital. Around 1935 he relocated to Indianapolis, established a private medical practice, and volunteered at Indianapolis General (City) Hospital's outpatient heart clinic. Middleton was accepted as a member of City Hospital staff in 1942 and joined the staffs at other Indianapolis hospitals. Middleton wrote several articles relating to cardiology that appear in state and national medical journals. He was a member of the American Medical Association, the National Medical Association, the American Heart Association, the Indiana State Medical Association, the Hoosier State Medical Society, and others.