Kayikçi grew up in
Heidelberg-Rohrbach and started her career at TSG Rohrbach. After a year in the federation league team (with 30 goals), she joined as a 16-year-old in the summer of 2008 to
Bundesliga team
FCR 2001 Duisburg and she debuted on 7 September 2008 against
Herforder SV. A week later they scored a 4–3 away win against
Hamburger SV; her first Bundesliga goal. In May 2011, Kayikçi moved to
SC Freiburg. In April 2012, she sustained a new cruciate ligament injury, which initially remained undetected. After a long break, she participated in their first Bundesliga game in the
2012–13 season and scored a goal. After three games, Kayikçi was again kept out of action by a knee injury. She could attend a game in the
2013–14 season. After a long pause and rehab, she celebrated her comeback in the Bundesliga at start of the 2014–15 season on 30 August 2014. Kayikçi became an important key player for the club and became team captain in 2021. In the 2022-23 season, she led her team to the
cup final, which was lost to Wolfsburg. In the semi-final she scored 1-0 to advance. In January 2025, Kayikçi announced she would retire at the end of the 2024–25 season after suffering another cruciate ligament injury in August 2024. She celebrated her comeback in the last game of the season in May 2025, being the last game in her career. Kayikçi is Freiburg's all-time Bundesliga top goalscorer. She holds the record for the club's most Bundesliga appearances. With 14 years at the club, she is one of Freiburg's most loyal players. In the summer of 2025, she continued her career at the Sport-Club in the management and scouting department. ==International career==