He sought the
Liberal nomination in
Renfrew—Nipissing—Pembroke in
1988, challenging the Liberal incumbent
Len Hopkins. More than 3,500 people voted in the nomination election, with Hopkins winning by a narrow margin. Clouthier announced he would once again seek the nomination in 1993, but his candidacy was denied by then-party leader
Jean Chrétien who protected Hopkins, who had held the seat for twenty-five years. Clouthier ran as an independent candidate in the
1993 federal election, getting over 10,000 votes and finishing second to Hopkins. In 1997, Hopkins announced he would not be a candidate in the
next federal election. There was a spirited battle for the Liberal nomination and over 4,000 memberships were sold. At the party's local convention, Clouthier defeated three other candidates to win the nomination. He subsequently won the general election and became MP for Renfrew—Nipissing—Pembroke. He was elected by his fellow Liberal MPs as Chair of the Eastern Ontario caucus, and was named by the Prime Minister as
Parliamentary Secretary to the Minister of National Defence in 2000. In the
2000 election he was defeated by
Canadian Alliance candidate
Cheryl Gallant, largely due to his controversial endorsement of
gun control, which had become highly unpopular in the region. After the election, he was asked by Prime Minister Jean Chrétien to be a Special Advisor in the
Prime Minister's Office. He served in the PMO until
Paul Martin took over as prime minister. Following a long absence from federal politics, Clouthier ran as an independent candidate in the
2011 federal election in his former riding of Renfrew-Nipissing-Pembroke. Clouthier placed a distant second to incumbent Gallant, receiving 18.70% of the vote to Gallant's 53.43. His tally of almost 10,000 votes was the most earned by any independent candidate in Ontario. In the
2015 federal election, Clouthier again stood as an independent. Following a nationwide surge for the Liberals, Clouthier's vote total fell, and he finished third behind Gallant and the Liberal candidate but, once again, received the most votes of any independent in Ontario. ==Personal life==