Heidi BigKnife was born in
Enid, Oklahoma and grew up in
Denver, Colorado, where her Shawnee mother worked in interior design. Her father trained pilots at the
Vance Air Force Base in Enid while in the service; he later worked as a
commercial pilot. She is enrolled in the Shawnee Nation. BigKnife has said that her career was influenced by her mother's artistic eye during her childhood. She remembers doing countless arts-and-crafts projects with her mother and developing the skill to "create something out of nothing." While in grade school, BigKnife was placed in a gifted and talented program through which she was allowed to tour various museums and view art that she would not otherwise have seen. In junior high, BigKnife enrolled in the drafting and shop classes to learn more about making items; she was the only female in the classes. During her high school years, BigKnife developed a love for photography that she carried into college, where she studied more.
Shawnee on her mother's side, BigKnife began to be more aware of her heritage and identify as Shawnee during her college years. After graduating from the Institute of American Indian Arts, she adopted her maternal grandmother's maiden name, BigKnife, as her surname. ==Education==