•
Ashley Judd as Helen Leonard, a college professor who is married to David, the ex-wife of Frank and mother of Julie. •
Goran Višnjić as David Leonard, Helen's husband and Julie's stepfather. •
Lauren Lee Smith as Mathilda, a young woman who Helen befriends during her treatment. •
Alexia Fast as Julie, Helen and Frank's daughter and David's stepdaughter. •
Alberta Watson as Dr. Sherman •
Leah Cairns as Susanna •
David Hewlett as Frank, Julie's biological father and Helen's ex-husband. It is later revealed that Frank has been aware of Helen's fragile mental state and her illness for quite some time which presumably later caused their marriage to fail. •
David Nykl as John •
Chelah Horsdal as Kara •
Conrad Coates as Stephen •
Veena Sood as Defense Attorney ==Release==