Coming out of high school, Hooker received numerous Power 5 offers. After visiting Virginia Tech's campus, Hooker committed to them in 2016, stating, "When we set foot on the big stage, on that game field, it just felt right". As a freshman in 2017, he competed with
redshirt freshman
Josh Jackson for the starting position at quarterback, but would ultimately end up getting redshirted before the beginning of the season in 2018. After the Hokies started off with two wins and two losses, Hendon won five games when he played, allowing the Hokies to be eligible for a bowl game. Hooker helped Virginia Tech qualify for the
Belk Bowl against
Kentucky in the 2019 season. In Virginia Tech's 8–5 season in 2019, Hooker had 1,555 passing yards, 13 passing touchdowns, and two interceptions to go along with 123 carries for 356 rushing yards and five rushing touchdowns. Two weeks later, against
Louisville, he completed all ten of his pass attempts for 183 passing yards to go along with 19 carries for 68 rushing yards and three rushing touchdowns in the 42–35 victory. On November 7, against
Liberty, he had 217 passing yards and three passing touchdowns to go along with 20 carries for 156 rushing yards and one rushing touchdown in the 38–35 loss. He finished with 1,339 passing yards, nine touchdowns, and five interceptions to go along with 120 carries for 620 rushing yards and nine rushing touchdowns in the Hokies' 5–6 season. During his career with Virginia Tech, he started 15 of 25 games, completing 197 of 312 passes for 2,894 yards, 22 touchdowns and seven interceptions.
Tennessee In 2021, Hooker transferred to the
University of Tennessee. Under head coach
Josh Heupel, he entered the 2021 season as the backup to
Joe Milton. Milton suffered an injury against
Pitt in the season's second game. Hooker came into the game in relief and helped lead Tennessee to a close loss to the Panthers. Hooker took over the starting job and produced numerous productive outings for Tennessee. He had six games with at least three passing touchdowns, which included a 316-yard, four-touchdown game in a 45–42 victory over
Kentucky and a 378-yard, five-touchdown game in a 48–45 overtime loss to
Purdue in the
Music City Bowl. He finished the 2021 season with 2,945 passing yards, 31 passing touchdowns, and three interceptions to go along with 166 carries for 616 rushing yards and five rushing touchdowns. He led the SEC in adjusted passing yards per attempt and passing efficiency rating. The Volunteers finished 2021 with a 7–6 record. Hooker returned to the Volunteers in 2022 for his final collegiate season. He started the season with two passing touchdowns and two rushing touchdowns in a 59–10 victory over
Ball State. In the following game against #17
Pitt, he passed for 325 yards and two touchdowns in the 34–27 overtime victory. He threw the go-ahead touchdown pass in overtime to
Cedric Tillman. Following a 63–6 victory over
Akron, the Vols reached a #11 ranking in the AP Poll. In the following game, Hooker passed for 349 yards and two passing touchdowns to go along with 112 rushing yards and a rushing touchdown in a 38–33 victory over
rival Florida. Hooker helped lead the #8 Vols to a 5–0 start following a 40–13 victory over #25
LSU. Tennessee's successful start to the season gave them a #6 ranking to set up an undefeated showdown with
longtime rival #3
Alabama. Hooker passed for 385 yards, five passing touchdowns, and one interception in the 52–49 victory over the Crimson Tide, Tennessee's first victory over Alabama since 2006. With the score tied at 49 late in the fourth quarter, Hooker led a drive down the field with two clutch throws to Ramel Keyton and
Bru McCoy to set up Chase McGrath's game-winning 40-yard field goal. All of Hooker's passing touchdowns in the Alabama game went to future
Biletnikoff Award winner
Jalin Hyatt. Hooker helped lead Tennessee to their first 6–0 start since 1998. Tennessee was propelled to a #3 ranking. For the first time in program history, Tennessee was named #1 in the first College Football Playoff rankings before a showdown with undefeated
Georgia, which was ranked #1 in the AP Poll. Tennessee reached #2 in the AP Poll, their highest ranking since 2001. On Senior Day, Hooker passed for 355 yards and three touchdowns to go along with a rushing touchdown in a 66–24 victory over
Missouri. Hooker’s collegiate career came to an abrupt end against
South Carolina when he suffered a torn ACL in a non contact injury in the fourth quarter of the 63–38 loss. In his second season with the Volunteers, Hooker started 11 games, completed 229 of 329 attempted passes for 3,135 yards, 27 touchdowns, and two interceptions. Towards the end of the season, Hooker finished fifth place in
Heisman Trophy voting. He became the first player from Tennessee to finish in the top five of Heisman Trophy voting since
Peyton Manning finished runner-up in 1997. He was named First-Team All-SEC and earned SEC Offensive Player of the Year for his 2022 season. He led the SEC in pass completion percentage and passing efficiency rating and the NCAA in passing yards per attempt and adjusted passing yards per attempt. Hooker was instrumental for a resurgent season for the Tennessee Volunteers football program. Tennessee's 11 wins, of which Hooker was the starting quarterback for nine of them, were the most for the program since 2001 and tied for the second-most in school history.
College statistics ==Professional career==