She married her cousin
Henry Casimir II, Prince of Nassau-Dietz, in 1683, at the age of 17. When Henry Casimir died in 1696, she became regent for their son,
John William Friso, who succeeded to his father's titles. Henriëtte Amalia von Anhalt-Dessau died in 1726 at the age of 59; she was buried in Dietz. Hendrik Casimir II and Henriëtte Amalia had nine children: • William George Friso (1685–1686) •
John William Friso (1687–1711), married
Marie Louise of Hesse-Kassel • Henriëtte Albertine (1686–1754) • Maria Amalia (1689–1771) • Sophia Hedwig (1690–1734), married
Karl Leopold, Duke of Mecklenburg-Schwerin (26 September 1678 – 28 November 1747) on 27 May 1709 (div. 1710) • Isabella Charlotte (1692–1757), married
Christian, Prince of Nassau-Dillenburg (1688–1739) • Johanna Agnes (1693–1765) • Louise Leopoldina (1695–1758) • Henriëtte Casimira (1696–1738) ==Ancestry==