In 1940, local pharmaceutical manufacturer Lee Hess converted the home into apartments, reserving one for himself and his wife. Hess had purchased the property in part for the extensive system of
caves under the property, which he opened as a tourist attraction. Newly christened by Hess as "Cherokee Cave" the caves were open to visitors until the demolition of its entrance underneath present-day
Interstate 55. Due to the discovery of the remains of a
peccary of the genus
Platygonus, the noted
paleontologist George Gaylord Simpson proceeded to move into the home, using it as a staging area for investigating the remains of prehistoric animals in the caves. The cave system had once served as the lagering cellars for the nearby Lemp Brewery in the Nineteenth Century. By the 1950s, the home was becoming derelict, and plans for
Interstate 55 called for the demolition of the home. However, a route change in 1961 permitted the home to be saved by the
Landmarks Association of St. Louis. The
Union Electric Company contributed to the purchase of the home and sponsored its renovation in concert with the Landmarks Association, and the
Missouri Department of Transportation agreed to the plan. In summer 1964, renovations began under the authority of architect
Gerhardt Kramer, and the home was dedicated the next year. The Landmarks Association created the Chatillon–DeMenil House Foundation as owner of the house, and it continues to operate the home as a museum. ==References==