MarketAcetyl hexapeptide-8
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Acetyl hexapeptide-8

Acetyl hexapeptide-8, also known as acetyl hexapeptide-8 amide and Argireline, is a synthetic hexapeptide used as a topical cosmetic ingredient that may improve the appearance of wrinkles. It is a small peptide fragment of SNAP25, a protein involved in neurotransmitter release and one of the targets of botulinum toxin type A, commonly known as Botox.

Overview and common uses
Acetyl hexapeptide-8 is used in attempts to decrease the visible effects of aging by reducing the deep wrinkles and lines that occur around the forehead and eyes. Chemically, when applied as a solution to specific areas of the face, acetyl hexapeptide-8 inhibits the reactions that cause muscles to move or contract – for example when forming facial expressions such as smiling or frowning. ==Research==
Research
Acetyl hexapeptide-8 has shown potential in improving the appearance of wrinkles, though the clinical significance of these effects remains uncertain due to inconsistent measurement methods and a lack of standardized clinical trials. ==Safety==
Safety
The 2012 study concluded there were no significant adverse effects. Patients receiving botulinum toxin injections exhibited longer times until return to baseline symptoms when supported with daily application of acetyl hexapeptide-8. Compared to botulinum toxin, acetyl hexapeptide-8 shows lower potency and toxicity, and no serious adverse effects reported. ==Chemistry==
Chemistry
Acetyl hexapeptide-8 is the hexapeptide with the amino acid sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2. ==References==
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