Highway 34 begins and ends on two other highways,
Highway 4 and
Highway 25, linking the two. Starting in the north, it turns left off Highway 4 to head south-east, whereas Highway 4 continues to the small
moshav of
Netiv HaAsara, and the
Erez Crossing with the Gaza Strip. Highway 34 then passes the
kibbutzim of
Erez and
Or HaNer, before heading towards
Sderot. There is no entrance to the north of the city, although as of 2024 there was some construction work in progress that will eventually form a link here. As the road passes under the hill of Givat Kobi, the Sderot lookout, it makes its closest approach to the
Gaza Strip, . It then reaches a junction for kibbutz
Nir Am, and shortly afterwards reaches the turning for Menachim Begin Road, which is the main entrance for Sderot and serves the
Sderot railway station. The next junction down is for
Route 232 (Israel). Finally, the road mostly heads straight for
Netivot, only punctuated by turnings for the moshavim
Yakhini and
Yoshivya before reaching
Highway 25, where the route ends (although Highway 25 is a
turn-off-to-stay-on, with the minor branch heading back to 232 and serving
Nahal Oz). ==Junctions (South to North)==