HMS Blandford was a 20-gun sixth-rate frigate of the Royal Navy. Launched in 1720, she was a member of the 1719 Establishment Group of 20-gun sixth rates. After being commissioned, she spent her career in the British Isles, the Baltic, North America and the Mediterranean on trade protection duties. After more than 20 years of service in the Royal Navy, she was sold at Deptford Dockyard in October 1742. Her new owner, the Bristol merchant James Pearce, refitted the vessel and entered her into the Atlantic slave trade. She made a single slave voyage before being sold again; her final fate is unknown. Blandford was the second named vessel since it was used for a 24-gun sixth rate launched at Woolwich on 29 October 1711 and lost with all hands in the Bay of Biscay on 23 March 1719.