4-HO-MET

In his book TiHKAL (Tryptamines I Have Known and Loved), Alexander Shulgin lists the dose range of 4-HO-MET as 10 to 20mg orally and its duration as 4 to 6hours. The drug's onset is said to be within 30minutes. ==Contraindications==

Pharmacodynamics 4-HO-MET binds to various serotonin receptors and is known to act as an agonist of the serotonin 5-HT2A, 5-HT2B, 5-HT2C, and 5-HT1A receptors. Pharmacokinetics The metabolism of 4-HO-MET has been studied. In vitro experiments using pooled human liver microsomes identified twelve metabolites. Four metabolites were detected in vivo from human urine, of which two were detected in vitro. ==Chemistry==

4-HO-MET, also known as 4-hydroxy-N-methyl-N-ethyltryptamine, is a substituted tryptamine and 4-hydroxytryptamine. Other analogues of 4-HO-MET include methylethyltryptamine (MET), 5-HO-MET, and 5-MeO-MET. ==History==

4-HO-MET was first synthesized and discovered by Alexander Shulgin in the 1970s. Subsequently, 4-HO-MET was described by Shulgin in his book TiHKAL (Tryptamines I Have Known and Loved) in 1997 as being- aside from its synthesis- indistinguishable from any other ethyl homologue. ==Society and culture==

Legal status Canada 4-HO-MET is not a controlled substance in Canada as of 2025. Finland Scheduled in the "government decree on psychoactive substances banned from the consumer market". Germany 4-HO-MET is ruled under the Neue-psychoaktive-Stoffe-Gesetz (NpSG) since July 18, 2019. Production and Import with intent to distribute is punishable. Possession is forbidden but not punishable, although ordering it in small quantities can still be seen as an intent to distribute it and be punished. 4-Propionoxy-N-methyl-N-ethyltryptamine (also referred to as 4-PrO-MET) is the ester prodrug of 4-HO-MET. Unlike many other tryptamine derivatives, it is currently not explicitly listed under the German Neue-psychoaktive-Stoffe-Gesetz (NpSG). This means that, while its use as a recreational substance is not legally permitted, the compound may be obtained and handled for legitimate research purposes, provided all other relevant legal requirements and safety regulations are observed. Sweden The Swedish Riksdag added 4-HO-MET to Schedule I ("substances, plant materials and fungi which normally do not have medical use") as narcotics in Sweden as of May 1, 2012, published by Medical Products Agency in their regulation LVFS 2012:6. United Kingdom 4-HO-MET is a class A drug in the United Kingdom, as a result of the tryptamine catch-all clause. United States 4-HO-MET is not scheduled at the federal level in the United States, but it is possible that it could be considered an analogue of psilocin, in which case purchase, sale, or possession could be prosecuted under the Federal Analogue Act. It is a schedule I substance in some states, such as South Dakota and West Virginia. ==See also==