Saquilayan was elected as vice mayor in 1998 and served until 2001, when he decided to challenge incumbent Mayor Oscar Jaro in his reelection bid. He defeated Jaro by only 748 votes. Jaro proceeded to contest the election results in all of the precincts and in January 2004, the Imus Regional Trial Court declared him the winner by 5,257 votes. In the elections that year, he and Jaro challenged each other again and defeated the latter by about 1,000 votes. Jaro filed an electoral protest again and was declared by the Imus Regional Trial Court the winner by 584 votes in 2007. In 2016 elections, Saquilayan decided to run as 3rd District Provincial Board Member under the
United Nationalist Alliance. His brother, City Councilor Edgardo Saquilayan run under ONE IMUS, a coalition between Imus City's
Liberal Party and UNA, with his rival, Mayor Maliksi and other LP candidates. In 2019, he ran as Mayor against incumbent Mayor Maliksi, but lost. In 2022 elections, he run for a vice mayoral post with his long-term political partner incumbent Rep. Alex 'AA' Advincula of the lone district of Imus City as his running mate.{{Cite web|last=Abrina |first=Dennis |work= Manila Times|url=https://www.manilatimes.net/2021/09/15/news/regions/cavite-political-clans-ready-their-bets-for-2022-polls/1814789|title = Cavite political clans ready their bets for 2022 polls ==References==