Until late November 2005, Hwang was criticized only for unpublicized
ethical violations. Colleagues and media outlets asserted that he had paid female donors for egg donations and that he had received donations from two junior researchers, both of which were violations. Later controversies centered around
scientific misconduct. His team, which cloned the first human
embryo to use for research, said they had used the same technology to create batches of embryonic stem cells from nine patients. According to Hwang, the result was much more efficient than they had hoped. Hwang's integrity as a researcher was again put in doubt when it was revealed that
PD Su-cheop had scheduled a follow-up report questioning his achievement published in
Science in June 2005, which stated he had cloned 11 lines of embryonic stem cells. This caused furious backlash among many South Koreans, and the reaction only intensified when it was discovered that Kim Sun-Jong, one of Hwang's researchers from MizMedi, had been coerced by illegal means to testify against Hwang. As a result, the scheduled broadcast was canceled and the network made a public apology to the nation, everyone more or less operating under the assumption that the show was at fault and not Hwang. Yet, other news outlets began to question Hwang's claims. Close scrutiny revealed that several of the photos of purportedly different cells were in fact photos of the same cell. Hwang responded that these additional photos were accidentally included and that there was no such duplication in the original submission to
Science. This was later confirmed by the journal. Researchers raised questions about striking similarities between the
DNA profiles of the cloned cells. Then collaborator Gerald Schatten asked
Science to remove his name from the paper, stating as a reason that there were "allegations from someone involved with the experiments that certain elements of the report may be fabricated." In the midst of national confusion, Hwang disappeared from public sight, to be hospitalized days later for alleged stress-related fatigue, while public opinion gradually began to turn against Hwang with even the major Korean companies who had withdrawn their support from
PD Su-cheop reportedly now less than pleased with Hwang. Days later, Hwang started going to his laboratory while requesting Seoul National University to officially conduct a probe to the allegations surrounding him. The scandal took a dramatic turn on December 15, when Roh Sung-il, who had collaborated on the disputed paper, stated to media outlets that nine of those eleven lines had been faked; specifically,
DNA tests illustrated that those nine lines shared identical
DNA, implying that they had come from the same source. Roh stated that "Professor Hwang admitted to fabrication", and that he, Hwang, and another co-author had asked
Science to withdraw the paper. Adding fuel to the fire, MBC broadcast the content of the canceled
PD Su-cheop show, which substantiated Roh's claim. On the same day,
The Seattle Times reported that
Science had not yet received an official request from Hwang to withdraw the paper, and it had refused to remove Schatten's name from the paper, stating, "No single author, having declared at the time of submission his full and complete confidence in the contents of the paper, can retract his name unilaterally, after publication." Several prominent scientists, including
Ian Wilmut, who cloned
Dolly the sheep in 1996, and
Bob Lanza, a cloning expert based in
Worcester, Massachusetts, did call on Hwang to submit his paper to an outside group for independent analysis. Lanza noted, "You can't fake the results if they're carried out by an independent group. I think this simple test could put the charges to rest." Two major
press conferences were held on Korean
television networks on December 16, one with Hwang, followed by one with his former colleague, Roh Sung-il. Hwang started his press conference by claiming that the technology to make stem cells existed—not an explicit denial that the stem cell lines he used in his paper to
Science were fakes. He, however, acknowledged the falsifications of research data in the paper, attributing them to unrecoverable "artificial mistakes". He said that there was a problem with the original lines caused by
contamination, and if he were given ten more days he could re-create the stem cell lines. He accused Kim Sun-Jong, a former collaborator, of "switching" some of the stem cell lines. Despite Hwang's claim, in another press conference held only minutes later, Roh Sung-il rebutted Hwang's accusation, saying Hwang was blackmailing MizMedi and Kim Sun-jong. He maintained that at least nine of the eleven stem cell lines were fakes and that Hwang was simply untrustworthy. "Roh Sung-il, chairman of the board at Mizmedi Hospital, told
KBS television that Hwang had agreed to ask the journal Science to withdraw the paper, published in June to international acclaim. Roh was one of the co-authors of the article that detailed how individual stem cell colonies were created for 11 patients through cloning. Roh also told
MBC television that Hwang had pressured a former scientist at his lab to fake data to make it look like there were 11 stem cell colonies. In a separate report, a former researcher told
MBC that Hwang ordered him to fabricate photos to make it appear there were 11 separate colonies from only three. [...] University of Pittsburgh researcher Gerald Schatten has already asked that Science remove him as the senior author of the report, citing questions about the paper's accuracy. Seoul National University announced this week it would conduct an internal probe into Hwang's research." Some scientists have started questioning Hwang's earlier work published in
Science in February 2004, in which he claimed to have cloned embryonic stem cells. Maria Biotech head Park Se-pill said, "Up until now, I have believed Hwang did derive cloned embryonic stem cells although he admitted to misconduct in his follow-up paper on patient-specific stem cells...Now, I am not sure whether the cloned stem cell really existed." On July 26, 2006, Hwang said in testimony that he spent part of 500 million won in private donations in attempts to clone extinct Russian mammoths and Korean tigers.
Official probe and confirmation of fraud An internal panel was set up in Seoul National University to investigate the allegation, and the probe was started on December 17, 2005. The panel sealed off Hwang's laboratory and conducted a thorough investigation, collecting testimonies from Hwang, Roh and other people who were involved with the scandal. On December 23, the panel announced its initial finding that Hwang had intentionally fabricated stem cell research results creating nine fake cell lines out of eleven, and added that the validity of two remaining cell lines is yet to be confirmed. The panel stated that Hwang's misconduct is "a grave act damaging the foundation of science." Hwang's claim of having used only 185 eggs to create stem cell lines was also denied by the panel, which indicated that more eggs may have been used in the research process. The panel announced additional findings on December 29, and confirmed that no patient-matched embryonic stem cells existed, and that Hwang's team did not have the scientific data to prove any of the stem cells had ever been made. In its final report published on January 10, 2006, the panel reaffirmed its previous findings while announcing additional discoveries. The panel found out that, contrary to Hwang's claim of having used 185 eggs for his team's 2005 paper, at least 273 eggs were shown to have been used according to research records kept in Hwang's lab. In addition, the panel discovered that Hwang's team was supplied with 2,061 eggs in the period of November 28, 2002, to December 8, 2005. Hwang's claim of not having known about the donation of eggs by his own female researchers was also denied by the panel; in fact, it was discovered that Hwang himself had distributed
egg donation consent forms to his researchers and personally escorted one to the MizMedi Hospital to perform the egg extraction procedure. The panel stated that Hwang's 2004
Science paper was also fabricated and decided the stem cell discussed in the paper may have been generated by a case of
parthenogenetic process (which is itself a significant development, as mammals rarely reproduce by parthenogenesis; in addition, this would make Hwang's lab the first ever to successfully generate human stem cells via parthenogenesis, predating other research facilities' successes). Although Hwang's team didn't rule out the possibility of parthenogenetic process in the paper, the panel said, his team didn't make any conscientious effort to probe the possibility through the tests available. Chung Myunghee, the head of the panel, said at a news conference that the panel was not in a position to investigate Hwang's claim of his stem cells having been switched with MizMedi's, but added that such a claim was incomprehensible when there were no data to prove any of the stem cells were ever made to begin with. However, the panel confirmed that Hwang's team had actually succeeded in cloning a dog they named
Snuppy, as results from analyses of 27 markers that allowed distinguishing amongst extremely-inbred animals and of mitochondrial DNA sequencing indicated that Snuppy was a somatic cell clone of Tie (the dog who gave the somatic cells required for Snuppy, which were then inserted into the eggs of surrogate mothers whose nuclei had been removed),
Resignation and the official dismissal On December 23, 2005, Hwang apologized for "creating a shock and a disappointment" and announced that he was resigning his position as professor at the university. However, Hwang maintained that patient-matched stem cell technology remained in South Korea, and his countrymen would see it. Seoul National University said Hwang's resignation request would not be accepted, citing a university regulation that dictates that an employee under investigation may not resign from a post, thus avoiding full retribution and possibly dismissal if found at fault, while benefiting from an honorable voluntary resignation. On February 9, 2006, the university suspended Hwang's position as a professor, together with six other faculty members who participated in Hwang's team; Hwang was dismissed on March 20, 2006.
Indictment of Hwang and collaborators On May 12, 2006, Hwang was indicted on charges of
embezzlement and breach of the country's
bioethics law, without physical
detention. Prosecutors also brought fraud charges against the three stem cell researchers. He embezzled 2.8 billion won (US$3 million) out of some 40 billion won in research funds, for personal purposes and the illegal purchase of ova used in his experiments. The prosecution also said Hwang's three associates involved in his stem cell research,
Yoon Hyun-soo,
Lee Byeong-chun and
Kang Sung-keun, also misappropriated tens of millions of won in research money. Investigators have been tracking 24.6 billion won to find out how the research money was spent. It was part of Hwang's 36.9 billion won research funds raised through state support and private donations. Investigators said Hwang used bank accounts held by relatives and subordinates in 2002 and 2003 to receive about 475 million won from private organizations. He allegedly laundered the money by withdrawing it all in cash, breaking it up into smaller amounts and putting it back in various bank accounts. Hwang also withdrew 140 million won in August 2001 to buy gifts for his sponsors, including politicians and other prominent social figures, before
Chusok holidays, according to prosecutors. He also allegedly misappropriated around 26 million won in research funds in September 2004 to buy a car for his wife. Hwang is suspected of embezzling 600 million won, provided by a private foundation, on multiple occasions from 2001 to 2005 for personal use. Prosecutors are also accusing him of illegally paying some 38 million won to 25 women who provided ova for his research through Hanna Women's Clinic in the first eight months of 2005. They also said Hwang gave several dozen politicians about 55 million won in political funds on numerous occasions from 2001 to 2005. He allegedly provided 14 million won to executives of large companies that provided financial support for his research. The prosecution added Hwang wired about 200 million won to a Korean American, identified only as Kang, in September 2005 and received the equivalent amount in U.S. currency from him when the scientist visited the United States two months later. Also in 2005, Hwang received one billion won each in research funds from
SK Group and the National Agricultural Cooperative Federation based on his fabricated stem cell research results. Meanwhile, investigators said Lee Byeong-chun and Kang Sung-keun, both professors of
veterinary science at Seoul National University, embezzled about 300 million won and 100 million won each in state funds by inflating research-related expenses. Yoon Hyun-soo, a biology professor at
Hanyang University, also embezzled 58 million won from the research fund managed by
MizMedi Hospital. ==Parthenogenesis==