Though some studies suggest the possible existence of hypoallergenic dog breeds, there is too much variability to conclude that such a breed exists. Pet dander is a cause of
allergic rhinitis for as much as 30% of the U.S. population. Some studies have suggested that the production of the allergen, and therefore human allergenic reaction, varies by breed, yet more recent scientific findings indicate that there are no significant differences between breeds in the generation of these allergens. Breeds that shed less are more likely to be hypoallergenic, since the dog's dander and saliva stick to the hair and are not released into the environment. However, protein expression levels play a major role and amount of shedding alone does not determine degree of allergic reaction. "Even if you get a hairless dog, it's still going to produce the allergen," states Dr. Wanda Phipatanakul, chair of the Indoor Allergen Committee for the
American Academy of Allergy, Asthma, and Immunology. If a person is allergic, they may be best able to tolerate a specific dog, possibly of one of the hypoallergenic breeds. Dr. Thomas A. Platts-Mills, head of the Asthma and Allergic Disease Center at the
University of Virginia, explained that there are cases in which a specific dog (not breed) might be better tolerated by a specific person, for unknown reasons. "We think there really are differences in protein production between dogs that may help one patient and not another," Dr. Platts-Mills said. Other breeds have come under scrutiny and Emma Charles, DVM discusses whether or not any particular breed of dog can be ever classed as hypoallergic. All dogs shed, and all dogs produce dander and saliva in some degree. As noted above, the amount of the allergenic protein present on the dander and in saliva varies by breed, but also by individual. The amount of the allergen can be reduced or eliminated in individual dogs by treatments such as bathing. But for most breeds, when not regularly bathed, even a dog who sheds very little or has little dander can trigger a reaction in a sensitive person. == Effect of size ==