Iacopo VI Appiani was the lord of Piombino from 1545 until his death, although he was expelled from his state between 1548 and 1557. He was the son and heir of Iacopo V and his wife, Elena, daughter of Giacomo Salviati. He was a child when he succeeded his father, and was placed under the protection of the Emperor Charles V, while his mother presided over a council of regency.