Detroit Lions Melifonwu was drafted in the third round, 101st overall, by the
Detroit Lions in the 2021 NFL Draft. Melifonwu signed his four-year rookie contract with Detroit on July 23, 2021. On September 22, 2021, Melifonwu was placed on
injured reserve after suffering a thigh injury in Week 2. He was activated on November 29. On June 1, 2022, Melifonwu started snaps as both a
cornerback and a
safety. On December 24, 2023, Melifonwu intercepted a pass from
Minnesota Vikings quarterback
Nick Mullens to end the game, clinching the Lions' first division title since 1993, and the first
NFC North title for the Lions. In the 2024 NFL season, Melifonwu suffered an ankle injury during training camp. He was placed on IR. Mid-season when the Lions opened his 21-day practice window, he dislocated his finger keeping him out for another month. He was able to return at the end of the season and impact his team. In Week 16 against the Bears, he knocked down a pass on 4th down.
Miami Dolphins On March 13, 2025, Melifonwu signed a one-year, $4 million contract with the
Miami Dolphins. ==NFL career statistics==