The
protein encoded by this gene is an accessory subunit of the heterodimeric
receptor for
IL18. This protein enhances the IL18 binding activity of
IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of
NF-κB and
MAPK8 (JNK) in response to IL18. ==Disease association==