Main •
Sergio Castellitto as Dr. Giovanni Mari, a psychologist in his 50s. •
Barbora Bobuľová as Lea (season 1–2), Dr. Mari's patient struggling with marital crisis. •
Adriano Giannini as Pietro (season 1–2), Lea's husband and Dr. Mari's patient struggling with marital crisis. •
Licia Maglietta as Anna (season 1–2), Mari's therapist. •
Kasia Smutniak as Sara (season 1), Dr. Mari's patient who's secretly in love with him. •
Guido Caprino as Dario (season 1), Dr. Mari's patient. He is an undercover policeman. • Irene Casagrande as Alice (season 1), Dr. Mari's patient struggling with suicide. • Francesco De Miranda as Mattia (season 2), Pietro and Lea's son. •
Maya Sansa as Irene (season 2), Dr. Mari's former patient and a successful lawyer. •
Michele Placido as Guido (season 2), Dr. Mari's patient struggling with panic attacks. •
Greta Scarano as Elisa (season 2), Dr. Mari's patient struggling with depression due to her cancer. •
Margherita Buy as Rita (season 3), a famous actress and Dr. Mari's patient. • Domenico Diele as Father Riccardo (season 3), a priest and Dr. Mari's patient. • Brenno Placido as Luca (season 3), a homosexual man with a passion for photography. •
Giulia Michelini as Bianca (season 3), Dr. Mari's patient struggling with anxiety. •
Giovanna Mezzogiorno as Adele (season 3), Mari's new therapist.
Recurring •
Valeria Golino as Eleonora Mari, Dr. Mari's wife. •
Valeria Bruni Tedeschi as Irene (season 1), Alice's mother. • Pier Giorgio Bellocchio as Sergio (season 1), Alice's father and Irene's husband. • Rodolfo Bianchi as Vittorio (season 1–2), Dario's father. •
Alba Rohrwacher as Lavinia (season 2), Guido's daughter. •
Isabella Ferrari as Mara (season 2), Dr. Mari's ex-girlfriend. • Daniele Antonini as Claudio (season 3), Bianca's husband. ==Production==