Together with her husband, she joined the Indian independence movement in 1921. She attended the 1931 Karachi session of the Indian National Congress and, at that time, requested leaders to hold the next session in Orissa. In 1932 after her release from Hazaribagh jail, she was actively involved in
Harijan welfare. She stated the
Asprushyata Nibarana Samiti under instructions from Gandhiji, for the eradication of untouchability. The institution was later renamed the
Harijan Sewa Sangha. She was closely involved in Gandhiji's 1932 and 1934 visits to Orissa as well as the visits of,
Kasturba,
Sardar Patel,
Rajendra Prasad,
Maulana Azad,
Jawaharlal Nehru and others. She started an Ashram at Bari, Orissa which Gandhiji named
Sewaghar. During the Quit India Movement of 1942, members of Rama Devi's entire family, including her husband, Gopabandhu Choudhury, were arrested. After the death of
Kasturba Gandhi,
Gandhji assigned her work as the representative of the Orissa chapter of the Kasturba Trust. ==Role after independence of India==