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Independent Spirit Award for Best Female Lead

The Independent Spirit Award for Best Female Lead was one of the annual Independent Spirit Awards to honor an actress who has delivered an outstanding lead performance in an independent film. It was first presented in 1985 with Geraldine Page being the first recipient of the award for her role as Carrie Watts in The Trip to Bountiful. It was last presented in 2022 with Taylour Paige being the final recipient of the award for her role in Zola.

Winners and nominees
won for The Trip to Bountiful. won for Blue Velvet. won for Anna. won for Five Corners. won for Sex, Lies, and Videotape. won for The Grifters. won for Impromptu. won for Leaving Las Vegas. won twice: Fargo (1996) and Three Billboards Outside Ebbing, Missouri (2017). won for Afterglow. won for Requiem for a Dream. won for In the Bedroom. has twice: Far from Heaven (2002) and Still Alice (2014). won for Monster. won for Frozen River. won for Precious. won for Black Swan. won for My Week with Marilyn. won for Silver Linings Playbook. won for Blue Jasmine. won for Room. won for Elle. won for The Wife. won for Promising Young Woman. was the final recipient for Zola. 1980s 1990s 2000s 2010s 2020s ==Multiple winners==
Multiple winners
;2 wins • Frances McDormandJulianne Moore ==Multiple nominees==
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