SR 105 begins at an intersection with
SR 9 east of
La Fontaine and runs north. The road has an intersection with
SR 218 about north of SR 9. North of SR 218, SR 105 passes through the community of
Banquo in rural southwestern Huntington County. The road has an intersection with
SR 124 west of
Mount Etna. The road then passes through
Lost Bridge State Recreation Area and crosses over the
Salamonie Lake. North of the lake SR 105 makes a sharp curve becoming east–west, before a second sharp curve that makes the road north–south once again. The road heads north towards
Andrews, passing through rural farm land on the way. On the way to Andrews SR 105 takes two more sharp curves. Shortly after the curves the highway enters the town of Andrews concurrent with Main Street and passing through residential areas. Main Street crosses a
Norfolk Southern rail track in the center of town. SR 105 leaves Andrews as it crosses over the
Wabash River and has an intersection with US 24. SR 105 heads southwest concurrent with US 24 as a four-lane divided highway, running roughly parallel to the Wabash River. After just over a mile SR 105 turns off of US 24 heading north towards
South Whitley. On the way to South Whitley the road crosses
SR 16 and passes through the community of
Bippus. After Bippus the route crosses
SR 114 and the Huntington–Whitley county line. In Whitley County SR 105 passes through rural farmland before entering South Whitley. On the south side of South Whitley the road curves and becomes east–west. The SR 105 designation ends at an intersection with
SR 5 crossing northwest–southeast and SR 14 continuing towards the east and north concurrent with SR 5. == History ==