State Road 161 begins in Spencer County approximately nine miles southwest of
Rockport at the northern end of the
Owensboro Bridge across the
Ohio River in the
Ohio Township. It goes north to
Reo. From there, it passes into Warrick County, where it has concurrencies with State Road 62 and State Road 68. At the north end of the county it passes over Interstate 64 three times in five miles (8 km), but the only interchange is at the last overpass. State Road 161 ends in Dubois County at
State Road 64 approximately four miles west of
Huntingburg. ==History==