The western terminus of SR 352 is at the Illinois border where
SR 26 and
Illinois Route 9 meet. SR 352 heads north along the Illinois–Indiana state line, for about a mile (), before making a sharp curve and running along the Warren–Benton county line. The road turns north before entering the town of Ambia. In town the road passes through residential areas and crosses a
Kankakee, Beaverville and Southern Railroad track. North of the railroad track SR 253 makes a sharp curve and parallels the tracks for a short distance, before SR 352 takes another sharp turning north. SR 352 takes one last sharp curve turning east, SR 352 proceeds directly east, passing through southern end of
SR 71. As the highway heads east towards the town of
Boswell it passes through agricultural land. In Boswell SR 352 passes through residential areas, before an intersection with
US 41. After US 41, SR 352 leaves Boswell, heading east towards
Oxford, passing through farmland and parallel to the Kankakee, Beaverville and Southern Railroad track. SR 352 enters the town of
Oxford and begins a concurrency with
SR 55. The concurrency heads east before turning north onto Justus Street. SR 55 and SR 352 head north on Justus Street for a block before turning east onto McConnell Street passing downtown Oxford. McConnell Street ends at Michigan Street with SR 55 turning north and SR 352 turning south onto Michigan Street. SR 352 heads south concurrent with Michigan Street for a block before turning east and leaving Oxford. East of Oxford SR 352 heads east passing through agricultural land, before crossing another railroad track owned by Kankakee, Beaverville and Southern Railroad. The eastern end of SR 352 is at an intersection with
US 52, northwest of Templeton, the roadway continues east as Benton County Road 600 South. ==History==