Benedetto Odescalchi was born in
Como on 16 May 1611, the son of a nobleman of Como, Livio Odescalchi, who died in 1626, and his wife Paola Castelli-Giovanelli from
Gandino, who died of the plague in 1630. The child's siblings were Carlo Odescalchi (1609 - 1673), married to Beatrice Cusani of the Marquesses of Chignolo (parents of Giovanna Odescalchi (1651 - 14 July 1679), married in
Milan on 27 May 1677 as his first wife to
Carlo Borromeo-Arese, 6th Marquess of Angera, 11th Count of Arona, with issue), Lucrezia Odescalchi (9 October 1605 - ?), married on 4 February 1621 to Alessandro Erba (6 November 1599 - 31 August 1670), son of Gerolamo Erba and wife Vittoria Olgiati, ancestors of the
Erba-Odescalchi,
Giulio Maria Odescalchi, Costantino Odescalchi, Nicola Odescalchi and Paolo Odescalchi. He also had several collateral descendants of note through his sister: her grandson Cardinal
Benedetto Erba Odescalchi and Cardinal
Carlo Odescalchi -
Servant of God. The
Odescalchi, a family of minor nobility, were determined entrepreneurs. In 1619, Benedetto's brother founded in
Genoa with his three uncles a bank which quickly grew into a successful money-lending business. After completing his studies in grammar and letters, the 15-year-old Benedetto moved to Genoa to take part in the family business as an apprentice. Lucrative economic transactions were established with clients in the major Italian and European cities, such as
Nuremberg,
Milan,
Kraków, and
Rome. In 1626, Benedetto's father died, and he began schooling in the humanities taught by the
Jesuits at his local college, before transferring to Genoa. In 1630, he narrowly survived an
outbreak of plague, which killed his mother. Some time between 1632 and 1636, Benedetto decided to move to Rome and then
Naples in order to study
civil law. This led to his securing the offices of
protonotary apostolic, president of the
Apostolic Camera, commissary of the Marco di Roma, and governor of
Macerata; on 6 March 1645,
Pope Innocent X (1644–55) made him
Cardinal-Deacon with the deaconry of
Santi Cosma e Damiano. He subsequently became
legate to
Ferrara. When he was sent to Ferrara in order to assist the people stricken with a severe famine, the Pope introduced him to the people of Ferrara as the "father of the poor". In 1650, Odescalchi became
bishop of Novara, in which capacity he spent all the revenues of his
see to relieve the poor and sick in his
diocese. He participated in the
1655 conclave. In 1656, with the pope's permission, he resigned as bishop of Novara in favour of his brother Giulio and moved to Rome. While there, he took a prominent part in the consultations of the various congregations of which he was a member. He participated in the
1669–70 conclave. ==Papacy==