Inositol trisphosphate The inositol-phospholipid signaling pathway is responsible for the generation of IP3 through the cleavage of
Phosphatidylinositol 4,5-bisphosphate (PIP2) found in the lipid bi-layer of the plasma membrane by
phospholipase C in response to either
receptor tyrosine kinase or
Gq alpha subunit-
G protein-coupled receptor signaling. Soluble
inositol trisphosphate (IP3) is able to rapidly diffuse into the cytosol and bind to the
inositol trisphosphate receptor (InsP3Rs) calcium channels located in the endoplasmic reticulum. This releases calcium into the cytosol, serving as a rapid and potent signal for various cellular processes.
Inositol hexaphosphate Inositol hexaphosphate (IP6) is the most abundant inositol phosphate isomer found. IP6 is solely involved in various biological activities such as neurotransmission, immune response, regulation of kinase and phosphatase proteins as well as activation of calcium channels. == References ==