The Intercalated cells of the amygdala are GABAergic neurons situated between the basolateral and central nuclei of the amygdala that play a significant role in inhibitory control over the amygdala. They regulate amygdala-dependent emotional processing like fear memory and social behavior. Their function has been best studied with selective ITC ablation which impairs fear extinction, fear generalization, and social behavior. Studies have begun to recognize that ITC clusters may be implicated in reward, addiction, and withdrawal circuits given their heavy expression of dopamine and opioid receptors.